Synthesis and antibacterial studies of lanthanide (III) complexes with aminopromazine

New complexes of lanthanide(III) nitrates with aminopromazine, having the general formula Ln(AP)(2)(NO3)(2)]NO3 (Ln = La, Cc, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu and AP = aminopromazine) have been synthesised. The complexes have been screened far antibacterial activities

Acute Appendicitis from Metastatic Small Cell Lung Cancer

[West J Emerg Med. 2012;13(1):94–95.

The Influence of Georgia’s Quality Rated System on School Readiness in Preschool Children

Background: Initially launched in 2012, the Quality Rated (QR) program in Georgia is a policy tool for assessing, improving, and communicating the quality of early childhood education and care. Star level designations – zero-star, one-star, two-star, and three-star – are assigned based on a portfolio of QR standards and an onsite Environment Rating Scales observation. In the present study, we used QR data to determine if childcare quality measures (QR ratings) are linked with the readiness of children to enter kindergarten. Methods: QR data were collected from one-star, two-star, and three-star childcare learning centers (n = 16) located within Child Care Resource and Referral Regions 3 and 5 in Georgia. The Bracken School Readiness Assessment – 3rd Edition (BSRA-3) was administered to each child (n =318) eligible for inclusion. Height and weight information (n =335) was collected before assessment. Multilevel analyses were used to establish whether children in programs that score higher on QR (0 to 3 stars) show better school readiness (i.e., by BSRA-3 assessment or body mass index) than peers in programs with lower scores. Results: For the children, there were no significant differences in scores of school readiness based on the QR of childcare and learning centers. Conclusions: The results reinforce the need for continued research of the childcare QR system in Georgia to inform stakeholders in early childcare and education about ways to enhance the quality of early child care and to improve the long-term educational and health outcomes of children across the state. Future studies should examine a larger sample size, which would allow for more precise, multilevel analyses

The effectiveness of progressive muscle relaxation and high intensity training on depression and quality of life in college students with polycystic ovarian syndrome

Background: Polycystic ovarian syndrome (PCOS) is a common hyper androgenic endocrine disorder affecting women of fertile age. This appears to have affects over the psychological aspects and health related quality of life of college students over a period of time. Leading to negative body imaging concern which causes loss of concentration in studies and interest in college activities.Methods: This was an experimental prospective study carried out with subjects diagnosed with PCOS aged 18-30 years. Self-administered PCOSQ and BDI questionnaire were used to evaluate the health related quality of life and depression. After the data collected from the questionnaire subjects received PMR and HIT for a duration of 6 days a week for 12 weeks’ convenient sampling main outcome variables were depression and quality of life. Self-menstrual tracking chart was also given to the students to monitor their menstrual cycle.Results: The prevalence of depression found in sample was 26% moderate, 19% borderline, 52% mild and 3% severe depression respectively. Age group in which commonly seen [18-20 years (n=14), 21-25 years (n=15)]. Patients also showed a negative impact of PCOS on health related QOL (PCOSQ) scale. After PMR and HIT data showed a statistically significant difference (p<0.05) between the pre-test and post-test scores of BDI.Conclusions: This study provides positive PMR and HIT is an effective therapy for improving the depression related to PCOS and thereby improving the quality of life of college students with PCOS

To Evaluate the Efficacy of Soft Tissue Diode Laser as an Adjunct to Scaling and Root Planning in the Management of Chronic Periodontitis: A Split Mouth study

BACKGROUND: Chronic periodontitis is an infectious disease resulting in inflammation of the supportive tissues of the teeth with the progressive attachment loss and bone loss. Thus, an essential component of therapy is to eliminate the etiological pathogens. This has been traditionally accomplished through mechanical means (SRP) scaling and root planing in non-surgical treatment modality for chronic periodontitis. AIM OF THE STUDY: To evaluate the efficacy of soft tissue diode laser as an adjunct to scaling and root planing following non-surgical treatment modality in the clinical parameters of adult patients with chronic periodontitis. MATERIALS AND METHODOLOGY: A total 30 systemically healthy subjects diagnosed with chronic periodontitis were randomly assigned in two groups; GROUP I (SRP): SRP alone done GROUP II (SRPL): Lasers was used as an adjunct to scaling and root planing. Baseline data, including plaque index (PI), gingival index (GI), probing pocket depth (PPD) and relative clinical attachment level (rCAL) were recorded before the treatment and 1st,3rd and 6th months after the treatment. RESULTS: The results were similar for both group in terms of plaque index (PI), gingival index (GI). The laser group showed only significant probing pocket depth and clinical attachment gain after the treatment. CONCLUSION: ◆ The results of this study show significant difference in PPD between GROUP I (SRP) and GROUP II (SRPL) at 6months interval from baseline. ◆ The results of this study show significant difference in CAL between GROUP I (SRP) and GROUP II (SRPL) at 6months interval from baseline. ◆ There was significant difference in PI and GI in both the groups from baseline to 6 months follow up. ◆ However, there was no significant difference in PI and GI between both groups I and II at 6 months interval

Financial Reporting and Moral Sentiments

Dating back at least to Adam Smith (1790), philosophers and researchers expect that people will behave differently when they know their actions are observable to others. We hypothesize that financial reporting reveals managers’ actions and leads them to take different actions that are better aligned with investor interests. We posit that the reason why is the activation of our internal mental self-evaluation that Smith refers to as an “Impartial Spectator.” We test this hypothesis with an experiment in which we manipulate the availability of a financial report that makes managerial actions transparent. Our evidence shows that financial reporting leads a manager to choose reinvestment and resource sharing actions that are better aligned with investor interests, even in a sparse experimental setting where the investor can impose no cost or confer no reward on the manager. This same effect holds in a setting where the investor can shut down the firm at any point and take a sizable portion of the assets. Our evidence is important because it suggests that part of financial reporting’s economic value comes from its enabling moral evaluation by the manager in addition to its traditional contracting function

Successful term pregnancy post laparoscopic management of thick perforate upper transverse vaginal septum

A 30-year-old woman presented with dyspareunia and infertility and was referred to after failure to visualize cervix during diagnostic laparoscopy by her primary consultant. Preoperative MRI was done which showed mild arcuate uterus with minimum fluid in vaginal cavity with vertical vaginal septum. This was managed successfully by a combined laparoscopic and vaginal approach. She conceived spontaneously and delivered a healthy term baby by caesarean section. Upper thick Transverse Vaginal Septum is a complex congenital malformation posing challenges for its correction, restoring normal healthy sex life and conception. The septum varies in thickness and may be located anywhere along the vagina reducing the functional length of the vagina.  Identifying and dissecting the anatomic structures is greatly aided by panoramic view of laparoscope allowing the surgeon to have an increased degree of freedom during surgery

Secukinumab sustains improvement in signs and symptoms of psoriatic arthritis: 2 year results from the phase 3 FUTURE 2 study

Objectives. To assess long-term efficacy, safety and tolerability of secukinumab up to 104 weeks in patients with active PsA. Methods. Patients with PsA (n = 397) were randomized to s.c. secukinumab 300, 150 or 75 mg or placebo at baseline, weeks 1, 2, 3 and 4 and every 4 weeks thereafter. Placebo-treated patients were re-randomized to receive secukinumab 300 or 150 mg s.c. from week 16 (placebo non-responders) or week 24 (placebo responders). Exploratory endpoints at week 104 included 20, 50 and 70% improvement in ACR criteria (ACR20, 50, 70); 75 and 90% improvement in the Psoriasis Area Severity Index, 28-joint DAS with CRP, presence of dactylitis and enthesitis and other patient-reported outcomes. For binary variables, missing values were imputed; continuous variables were analysed by a mixed-effects model for repeated measures. Results. A total of 86/100 (86%), 76/100 (76%) and 65/99 (66%) patients in the secukinumab 300, 150 and 75 mg groups, respectively, completed 104 weeks. At week 104, ACR20 response rates after multiple imputation in the 300, 150 and 75 mg groups were 69.4, 64.4 and 50.3%, respectively. Sustained clinical improvements were observed through week 104 with secukinumab across other clinically important domains of PsA. Responses were sustained through week 104 regardless of prior anti-TNF-a use. Over the entire treatment period the incidence, type and severity of adverse events were consistent with those reported previously. Conclusion. Secukinumab provided sustained improvements in signs and symptoms and multiple clinical domains in patients of active PsA through 2 years of therapy. Secukinumab was well tolerated, with a safety profile consistent with that reported previously. Trial registration: ClinicalTrials.gov (https://clinicaltrials.gov), NCT0175263

Role of thyroid function tests in women with abnormal uterine bleeding

Background: A relationship between the thyroid gland and the gonads is suggested by the far more frequent occurrence of thyroid disorders in women than in men and by the common appearance of goiter during puberty, pregnancy and the menopause. Both hypothyroidism and hyperthyroidism may result in menstrual disturbances. Objective of current study is to study and correlate the thyroid function tests in women with abnormal uterine bleeding.Methods: After selecting the women, informed consent was obtained. The case history and clinical examination of them were done, requested to do thyroid functioning test in fasting status in early morning and the results were evaluated. Other required investigations as per requirement were done and the patients were managed accordingly. The thyroid function tests were done by radioimmuno assays in the lab.Results: There were 170 women who were included in the study. Out of all the types of menstrual irregularities, 50% (85) presented with oligomenorrhoea. We found that 132 women had normal thyroid status while 30 women had hypothyroidism out of them, 5 had subclinical hypothyroidism. Eight women had hyperthyroidism.Conclusions: As there is high incidence of thyroid diseases in our area, women with abnormal uterine bleeding are to be screened. This would also avoid unnecessary hormonal treatment and surgery in these patients

Sodium-glucose co-transporter-2 inhibitors as anti-diabetic agents: a review

The incidence and prevalence of Type 2 diabetes mellitus (T2DM) have been increasing worldwide. However, existing therapeutic classes of anti-diabetic drugs are not adequately effective in achieving and maintaining long-term glycemic control in the most patients. The majority of the drugs control blood sugar without addressing the basic pathology of insulin resistance and relative deficiency. Moreover, side effects such as hypoglycemia and weight gain, of both new and established drugs need to be considered prior to treating a patient. An emerging anti-hyperglycemic intervention, the sodium glucose co-transporter 2 (SGLT2) inhibitor acts by a novel mechanism. Under physiological conditions, SGLT2 accounts for 90% of the glucose re-absorption in the kidney, while the SGLT2 inhibitors result in an increase in urinary excretion of glucose and lower plasma glucose levels. Here, the pros and cons of SGLT2 inhibitors are considered, while approaching a patient with T2DM. The basic biochemistry and physiology underlying the mechanisms of SGLT2 inhibitors are discussed alongside its clinical pharmacology, with a focus on metabolic changes associated with urinary glucose loss. Finally, a consideration of Food and Drug Administration safety concerns associated with acidosis due to SGLT2 inhibitor usage is presented, to allow a complete understanding of the utility of these molecules in the light of existing T2DM therapies